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1980 Topps remained at 726 cards. The card fronts feature a large color portrait of the player with a facsimile autograph. The players name is positioned along the top border of the card. The players position is inside a pennant at the top left and the team is inside another pennant along the bottom right. The back of these cards contain player statistics, biographical information and a cartoon about the player. Many rookies appear in team threesome cards.

Sub sets include Statistical Leaders (LL) and Previous Seasons Highlights (HL).